Better methods of embryo selection are needed to improve in vitro fertilization (IVF) efficiency. New research shows that high quantities of mitochondrial DNA (mtDNA) may be a meaningful marker for embryo viability beyond current measures, as normal chromosome counts and high morphological grade have not guaranteed successful pregnancy of embryos. mtDNA is a useful marker of embryonic implantation potential, independent of embryo quality and female age, according to an abstract presented at the European Society of Human Reproduction and Embryology annual meeting (Helsinki, Finland; July 3-6). The authors, from 9.baby Family and Fertility Center in Italy, say that incorporation of mtDNA copy number analysis into the routine preimplantation genetic screening (PGS) may aid selection of the euploid blastocysts with the best chances to implant. The researchers analyzed data from 54 euploid blastocysts obtained from 26 patients (average age 35.5 years) following 29 PGS cycles. Blastocysts quality was assessed and categorized as good or bad quality based on morphology and expansion. Biopsy was performed on Day 5-6 and comprehensive chromosome screening was conducted using array comparative genomic hybridization. mtDNA content for each of 54 euploid blastocysts was quantified using real-time polymerase chain reaction (PCR) and blastocysts were categorized based on a […]