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Evidence Lacking to Evaluate Celiac Screening The U.S. Preventive Services Task Force (USPSTF) found there is not enough evidence to advocate for or against screening asymptomatic adults, adolescents, and children for celiac disease, according to the recommendation, published March 28 in the Journal of the American Medical Association. The standard method of diagnosing celiac disease in symptomatic patients (older than 2 years) is the tissue transglutaminase IgA test, followed by intestinal biopsy for histologic confirmation. The finding includes a lack of evidence for targeted screening of those that are asymptomatic, but at high risk for the disease due to family history or other autoimmune disorders. USPSTF reports inadequate evidence regarding the accuracy, effectiveness, and benefits/harms of screening with regard to morbidity, mortality, or quality of life. USPSTF suggests the need for future studies, particularly in high-risk populations, that randomly assign participants to screening or no screening to evaluate clinical outcomes. Consensus Diagnosis Recommendations for Congenital Cytomegalovirus Infection An informal International Congenital Cytomegalovirus Recommendations Group recently published consensus guidelines in The Lancet Infectious Disease against universal screening of mothers for primary infection. The group recommended "consideration" of universal neonatal screening for cytomegalovirus to facilitate early detection and intervention to minimize long-term, […]

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