GENETIC TESTING

Most Oncologists Report Using Sequencing-Based Panels In Practice

The majority of U.S. oncologists report using next-generation sequencing-based (NGS-based) tests to guide patient care, according to a study published Nov. 13 in JCO Precision Oncology, although use … [Read more...]

SPECIAL FOCUS

Evidence Building for Use of Liquid Biopsy to Drive Treatment Decisions, Monitor Disease Activity

Emerging evidence shows that liquid biopsy is a viable option for detecting and monitoring genomic mutations to inform treatment decisions and to assess disease activity in real-world clinical … [Read more...]

EMERGING TESTS

Polygenic Risk Score Predicts Drug Efficacy with Schizophrenia

A polygenic risk score (PRS) may be able to predict response to antipsychotic drug treatment in patients with their first episode of psychosis from schizophrenia, according to a study published Nov. 5 … [Read more...]

GUIDELINES

Pre-Op Urine Screening Not Necessary

Routine preoperative urine screening offers no clinical benefit, according to a large study published Dec. 12 in JAMA Surgery. Treating asymptomatic bacteriuria detected by screening does not cut the … [Read more...]

INFORMATICS

Big Data Can Reshape Lab Reference Values in the Era of Personalized Medicine

As might be expected, there are substantial differences in "normal" laboratory values determined by healthy outpatients and critically ill patients in the intensive care unit (ICU). However, even … [Read more...]

PRECISION MEDICINE

Panel Size Affects Accuracy of Tumor Mutational Burden Calculation

Panel size is a critical determinant of test performance and cutoff values for determining the tumor mutational burden (TMB) to guide treatment decisions with immunotherapies, according to a study … [Read more...]

GENETIC TESTING

Sequencing-Based Panel May Improve Evaluation of Thyroid Nodules

A genetic test panel can help patients avoid unnecessary diagnostic thyroid surgeries, according to a study published Nov. 8 in JAMA Oncology. More than six in 10 of patients with thyroid nodules of … [Read more...]

EMERGING TESTS

At-Home, Smartphone-Based Urine Testing Now a Clinical Reality

In what has been called the "era of the medical selfie," at-home, smartphone-based urine testing is now a reality. In a short timeframe, the U.S. Food and Drug Administration (FDA) cleared … [Read more...]

INDUSTRY TRENDS

Despite 23andMe Authorization, FDA Cautious About PGx Testing

The U.S. Food and Drug Administration (FDA) provided 23andMe (Mountain View, Calif.) authorization for the first direct-to-consumer (DTC) test for detecting genetic variants that may be associated … [Read more...]

GUIDELINES

Ideal Age of Last Cervical Cancer Screening Depends on Test Type

With the adoption of cotesting—human papillomavirus (HPV) plus Pap cytology—cervical cancer screening methodology has focused primarily on the preferred frequency of combined testing. However, a new … [Read more...]


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